{"id":633,"date":"2026-06-26T15:13:23","date_gmt":"2026-06-26T13:13:23","guid":{"rendered":"https:\/\/studienportal-endometriumkrebs.de\/pynnacle-study\/"},"modified":"2026-07-20T16:50:42","modified_gmt":"2026-07-20T14:50:42","slug":"pynnacle-study","status":"publish","type":"post","link":"https:\/\/studienportal-endometriumkrebs.de\/en\/pynnacle-study\/","title":{"rendered":"PYNNACLE STUDY"},"content":{"rendered":"\t\t
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PYNNACLE STUDY<\/strong><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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THERAPY STUDY TO EVALUATE THE EFFICACY AND SAFETY OF THE NEW ACTIVE SUBSTANCE REZATAPOPT IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The PYNNACLE study is a phase 1\/2 clinical trial investigating a new medication called Rezatapopt. The study is aimed at patients with various advanced or metastatic cancers (e.g., ovarian, breast, lung, or endometrial cancer) whose tumor has a specific genetic alteration called the TP53-Y220C mutation. The objective is to determine how safe and effective Rezatapopt is and which dose is most suitable.<\/p>

Participation:<\/strong><\/p>

Further information about the study and centers where participation is possible can be found on the study homepage: https:\/\/www.pynnaclestudy.com\/<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tCheck eligibility for participation<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

PYNNACLE STUDY THERAPY STUDY TO EVALUATE THE EFFICACY AND SAFETY OF THE NEW ACTIVE SUBSTANCE REZATAPOPT IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS The PYNNACLE study is a phase 1\/2 clinical trial investigating a new medication called Rezatapopt. The study is aimed at patients with various advanced or metastatic cancers (e.g., ovarian, breast, […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[23],"tags":[],"class_list":["post-633","post","type-post","status-publish","format-standard","hentry","category-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/posts\/633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/comments?post=633"}],"version-history":[{"count":1,"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/posts\/633\/revisions"}],"predecessor-version":[{"id":634,"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/posts\/633\/revisions\/634"}],"wp:attachment":[{"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/media?parent=633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/categories?post=633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/studienportal-endometriumkrebs.de\/en\/wp-json\/wp\/v2\/tags?post=633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}